Cell cycle parameters in human solid tumors
نویسندگان
چکیده
منابع مشابه
Development of cell-cycle checkpoint therapy for solid tumors.
Cellular proliferation is tightly controlled by several cell-cycle checkpoint proteins. In cancer, the genes encoding these proteins are often disrupted and cause unrestrained cancer growth. The proteins are over-expressed in many malignancies; thus, they are potential targets for anti-cancer therapies. These proteins include cyclin-dependent kinase, checkpoint kinase, WEE1 kinase, aurora kinas...
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Results of labeled mitoses and repeated labeling experiments are presented for the Ehrlich ascites tumor at 2, 6, and 10 days after implantation of 1.7 X 106 cells, and for the solid Ehrlich tumor in the weight range 0.4-1.8 gm. Computer methods were used to fit curves to the experimental points. In the ascitic form of the tumor all phases of the cell cycle increased with tumor age, and the DNA...
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ژورنال
عنوان ژورنال: Cancer
سال: 1977
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197710)40:4<1453::aid-cncr2820400416>3.0.co;2-e